Manami Nishi: A Prominent Researcher in Parasitology
Manami Nishi is a scientist who has made significant contributions to the field of parasitology, especially on the motility and egress of Toxoplasma gondii, a human parasite that can cause congenital defects and opportunistic infections. In this article, we will introduce her research works and achievements, as well as some interesting facts about her.
Research Works and Achievements
Manami Nishi has published 17 research papers on ResearchGate, with 715 citations and 1,499 reads. Her most cited paper is “The Motility of a Human Parasite, Toxoplasma gondii, Is Regulated by a Novel Lysine Methyltransferase”, which was published in PLoS Pathogens in 2011. In this paper, she and her co-authors discovered a novel enzyme that regulates the movement and exit of Toxoplasma gondii from host cells. This enzyme, called AKMT, methylates a protein called actin, which is essential for the parasite’s motility. By manipulating the expression of AKMT, they were able to alter the parasite’s behavior and infectivity. This finding has implications for developing new drugs and vaccines against toxoplasmosis.
Another notable paper by Manami Nishi is “A Plant-Like Vacuolar H+-Pyrophosphatase in Plasmodium falciparum”, which was published in Nature Communications in 2012. In this paper, she and her co-authors identified a novel enzyme that pumps protons into the vacuole of Plasmodium falciparum, the causative agent of malaria. This enzyme, called PfVP1, is similar to plant enzymes that maintain the acidity and osmolarity of plant vacuoles. They showed that PfVP1 is essential for the parasite’s survival and drug resistance. This finding suggests that PfVP1 could be a potential target for antimalarial drugs.
Here are some interesting facts about Manami Nishi that you may not know:
She is affiliated with Indiana University Bloomington and other places.
She has a Facebook profile with 10 friends.
She likes to watch live video microscopy of parasite egress.
Manami Nishi is a prominent researcher in parasitology who has made important discoveries on the motility and egress of Toxoplasma gondii and the vacuolar proton pump of Plasmodium falciparum. Her research works have implications for developing new interventions against these human parasites. She is also an active member of the scientific community who has a social media presence and an interest in live video microscopy.
Manami Nishi’s research works have opened new avenues for exploring the molecular mechanisms and functions of parasite motility and egress. Some of the future directions that she and other researchers could pursue are:
Elucidating the structure and function of AKMT and its substrates in Toxoplasma gondii and other apicomplexan parasites.
Investigating the regulation and dynamics of actin methylation and its role in parasite-host interactions.
Identifying and characterizing the inhibitors and activators of AKMT and PfVP1 as potential antiparasitic agents.
Comparing and contrasting the vacuolar proton pumps of different parasites and their evolutionary origins.
Understanding the physiological and pathological roles of vacuolar acidification and osmoregulation in parasite survival and virulence.
With these and other research questions, Manami Nishi and her colleagues will continue to advance the knowledge and innovation in parasitology and contribute to the global health efforts against parasitic diseases.